Chymkowitch P, Nguéa A, Aanes H, Koehler CJ, Thiede T, Lorenz S, Meza-Zepeda LA, Arne Klungland A and Enserink JM. Sumoylation of Rap1 Mediates the Recruitment of TFIID to Promote Transcription of Ribosomal Protein Genes. Genome Research. (2015) Mar 23. [Epub ahead of print].2023
Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer. Carm KT, Johannessen B, Bogaard M, Bakken AC, Maltau AV, Hoff AM, Axcrona U, Axcrona K, Lothe RA, Skotheim RI.Int J Cancer. 2023 Mar 1;152(5):945-951. doi: 10.1002/ijc.34226. Epub 2022 Aug 9.PMID: 35880692
Cooperative induction of receptor tyrosine kinases contributes to adaptive MAPK drug resistance in melanoma through the PI3K pathway. Alver TN, Heintz KM, Hovig E, Bøe SL.Cancer Rep (Hoboken). 2023 Feb;6(2):e1736. doi: 10.1002/cnr2.1736. Epub 2022 Oct 17.PMID: 36251678
Gene Regulatory Interactions at Lamina-Associated Domains. Madsen-Østerbye J, Abdelhalim M, Pickering SH, Collas P.Genes (Basel). 2023 Jan 28;14(2):334. doi: 10.3390/genes14020334.PMID: 36833261
Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation. Panagopoulos I, Andersen K, Brunetti M, Gorunova L, Lund-Iversen M, Micci F, Heim S.In Vivo. 2023 Mar-Apr;37(2):524-530. doi: 10.21873/invivo.13110.PMID: 36881074
Genomic Complexity as a Biomarker to De-Escalate Adjuvant Imatinib Treatment in High-Risk Gastrointestinal Stromal Tumor. Boye K, Gorunova L, Gunawan B, Hompland I, Sander B, Panagopoulos I, Langer C, Golas M, Heim S, Füzesi L, Hølmebakk T, Micci F.JCO Precis Oncol. 2023 Feb;7:e2200351. doi: 10.1200/PO.22.00351.PMID: 36724411
Novel MYCBP::EHD2 and RUNX1::ZNF780A Fusion Genes in T-cell Acute Lymphoblastic Leukemia.Panagopoulos I, Andersen K, Rinvoll Johannsdottir IM, Micci F, Heim S.Cancer Genomics Proteomics. 2023 Jan-Feb;20(1):51-63. doi: 10.21873/cgp.20364.PMID: 36581344
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma. Spasevska I, Sharma A, Steen CB, Josefsson SE, Blaker YN, Kolstad A, Rustad EH, Meyer S, Isaksen K, Chellappa S, Kushekhar K, Beiske K, Førsund MS, Spetalen S, Holte H, Østenstad B, Brodtkorb M, Kimby E, Olweus J, Taskén K, Newman AM, Lorenz S, Smeland EB, Alizadeh AA, Huse K, Myklebust JH.Blood Adv. 2023 Dec 12;7(23):7216-7230. doi: 10.1182/bloodadvances.2023010158.PMID: 37695745
Human small intestine contains 2 functionally distinct regulatory T-cell subsets. Chauhan SK, Bartolomé Casado R, Landsverk OJB, Johannessen H, Phung D, Nilsen HR, Sætre F, Jahnsen J, Horneland R, Yaqub S, Aandahl EM, Lundin KEA, Bækkevold ES, Jahnsen FL.J Allergy Clin Immunol. 2023 Jul;152(1):278-289.e6. doi: 10.1016/j.jaci.2023.02.030. Epub 2023 Mar 8.PMID: 36893861
The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma. Nunes-Xavier CE, Emaldi M, Mingo J, Øyjord T, Mælandsmo GM, Fodstad Ø, Errarte P, Larrinaga G, Llarena R, López JI, Pulido R.Sci Rep. 2023 May 5;13(1):7339. doi: 10.1038/s41598-023-34087-x.PMID: 37147361
Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling.Brynjulvsen M, Solli E, Walewska M, Zucknick M, Djirackor L, Langmoen IA, Mughal AA, Skaga E, Vik-Mo EO, Sandberg CJ.Cancers (Basel). 2023 Dec 13;15(24):5826. doi: 10.3390/cancers15245826.PMID: 38136371
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood. Kresse SH, Brandt-Winge S, Pharo H, Flatin BTB, Jeanmougin M, Vedeld HM, Lind GE.Clin Epigenetics. 2023 Sep 14;15(1):151. doi: 10.1186/s13148-023-01563-0.PMID: 37710283
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease. Małecka A, Østlie I, Trøen G, Małecki J, Delabie J, Tierens A, Munthe LA, Berentsen S, Tjønnfjord GE.Clin Exp Immunol. 2023 Dec 22:uxad135. doi: 10.1093/cei/uxad135. Online ahead of print.PMID: 38133636
The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition. Anzar I, Malone B, Samarakoon P, Vardaxis I, Simovski B, Fontenelle H, Meza-Zepeda LA, Stratford R, Keung EZ, Burgess M, Tawbi HA, Myklebost O, Clancy T.Front Immunol. 2023 Sep 20;14:1226445. doi: 10.3389/fimmu.2023.1226445. eCollection 2023.PMID: 37799721
Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential. Namløs HM, Khelik K, Nakken S, Vodák D, Hovig E, Myklebost O, Boye K, Meza-Zepeda LA.Mol Oncol. 2023 Nov;17(11):2432-2450. doi: 10.1002/1878-0261.13514. Epub 2023 Sep 3.PMID: 37622176
Heritable defects in telomere and mitotic function selectively predispose to sarcomas.
Ballinger ML, Pattnaik S, Mundra PA, Zaheed M, Rath E, Priestley P, Baber J, Ray-Coquard I, Isambert N, Causeret S, van der Graaf WTA, Puri A, Duffaud F, Le Cesne A, Seddon B, Chandrasekar C, Schiffman JD, Brohl AS, James PA, Kurtz JE, Penel N, Myklebost O, Meza-Zepeda LA, Pickett H, Kansara M, Waddell N, Kondrashova O, Pearson JV, Barbour AP, Li S, Nguyen TL, Fatkin D, Graham RM, Giannoulatou E, Green MJ, Kaplan W, Ravishankar S, Copty J, Powell JE, Cuppen E, van Eijk K, Veldink J, Ahn JH, Kim JE, Randall RL, Tucker K, Judson I, Sarin R, Ludwig T, Genin E, Deleuze JF; French Exome Project Consortium; Haber M, Marshall G, Cairns MJ, Blay JY; International Sarcoma Kindred Study; Thomas DM, Tattersall M, Neuhaus S, Lewis C, Tucker K, Carey-Smith R, Wood D, Porceddu S, Dickinson I, Thorne H, James P, Ray-Coquard I, Blay JY, Cassier P, Le Cesne A, Duffaud F, Penel N, Isambert N, Kurtz JE, Puri A, Sarin R, Ahn JH, Kim JE, Ward I, Judson I, van der Graaf W, Seddon B, Chandrasekar C, Rickar R, Hennig I, Schiffman J, Randall RL, Silvestri A, Zaratzian A, Tayao M, Walwyn K, Niedermayr E, Mang D, Clark R, Thorpe T, MacDonald J, Riddell K, Mar J, Fennelly V, Wicht A, Zielony B, Galligan E, G…See abstract for full author list ➔Science. 2023 Jan 20;379(6629):253-260. doi: 10.1126/science.abj4784. Epub 2023 Jan 19.PMID: 366569282022
Atezolizumab plus anthracycline-based chemotherapy in metastatic triple-negative breast cancer: the randomized, double-blind phase 2b ALICE trial. Andreas Hagen Røssevold 1 2, Nikolai Kragøe Andresen 1 2, Christina Annette Bjerre 3, Bjørnar Gilje 4, Erik Hugger Jakobsen 5, Sunil Xavier Raj 6, Ragnhild Sørum Falk 7, Hege Giercksky Russnes 8, Thea Jahr 9, Randi Ruud Mathiesen 10, Jon Lømo 8, Øystein Garred 8, Sudhir Kumar Chauhan 2, Ragnhild Reehorst Lereim 2, Claire Dunn 2, Bjørn Naume 10 11, Jon Amund Kyte 12 13 PMID: 36482103, PMCID: PMC9800277, DOI: 10.1038/s41591-022-02126-1
A national precision cancer medicine implementation initiative for Norway. Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES; CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R; InPreD-Norway and National Molecular Tumor Board Consortium; IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å.Nat Med. 2022 May;28(5):885-887. doi: 10.1038/s41591-022-01777-4.PMID: 35513529
miR-486-5p expression is regulated by DNA methylation in osteosarcoma. Namløs HM, Skårn M, Ahmed D, Grad I, Andresen K, Kresse SH, Munthe E, Serra M, Scotlandi K, Llombart-Bosch A, Myklebost O, Lind GE, Meza-Zepeda LA.BMC Genomics. 2022 Feb 17;23(1):142. doi: 10.1186/s12864-022-08346-6.PMID: 35172717
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D, Hjortland GO, Hovig E, Hovland R, Iversen AC, Janssen E, Kyte JA, von der Lippe Gythfeldt H, Lothe R, Lund JÅ, Meza-Zepeda L, Munthe-Kaas MC, Nguyen OTD, Niehusmann P, Nilsen H, Puco K, Ree AH, Riste TB, Semb K, Steinskog ESS, Stensvold A, Suhrke P, Tennøe Ø, Tjønnfjord GE, Vassbotn LJ, Aas E, Aasebø K, Tasken K, Smeland S. J Transl Med. 2022 May 14;20(1):225. doi: 10.1186/s12967-022-03432-5.PMID: 35568909
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence. Misund K, Hofste Op Bruinink D, Coward E, Hoogenboezem RM, Rustad EH, Sanders MA, Rye M, Sponaas AM, van der Holt B, Zweegman S, Hovig E, Meza-Zepeda LA, Sundan A, Myklebost O, Sonneveld P, Waage A.Leukemia. 2022 Jul;36(7):1887-1897. doi: 10.1038/s41375-022-01597-y. Epub 2022 May 28.PMID: 35643867
Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy. Venizelos A, Engebrethsen C, Deng W, Geisler J, Geisler S, Iversen GT, Aas T, Aase HS, Seyedzadeh M, Steinskog ES, Myklebost O, Nakken S, Vodak D, Hovig E, Meza-Zepeda LA, Lønning PE, Knappskog S, Eikesdal HP.Genome Med. 2022 Aug 11;14(1):86. doi: 10.1186/s13073-022-01090-2.PMID: 35948919
Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia. Sohlberg E, Pfefferle A, Heggernes Ask E, Tschan-Plessl A, Jacobs B, Netskar H, Lorenz S, Kanaya M, Kosugi-Kanaya M, Meinke S, Mörtberg A, Höglund P, Sundin M, Carlsson G, Palmblad J, Malmberg KJ.Blood. 2022 Feb 3;139(5):704-716. doi: 10.1182/blood.2021013233.PMID: 34699594
A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer. Høye E, Fromm B, Böttger PHM, Domanska D, Torgunrud A, Lund-Andersen C, Abrahamsen TW, Fretland ÅA, Dagenborg VJ, Lorenz S, Edwin B, Hovig E, Flatmark K.NAR Cancer. 2022 Jan 14;4(1):zcab051. doi: 10.1093/narcan/zcab051. eCollection 2022 Mar.PMID: 35047825
A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer. Høye E, Fromm B, Böttger PHM, Domanska D, Torgunrud A, Lund-Andersen C, Abrahamsen TW, Fretland ÅA, Dagenborg VJ, Lorenz S, Edwin B, Hovig E, Flatmark K.NAR Cancer. 2022 Jan 14;4(1):zcab051. doi: 10.1093/narcan/zcab051. eCollection 2022 Mar.PMID: 35047825
Epigenetic alterations at distal enhancers are linked to proliferation in human breast cancer. Ankill J, Aure MR, Bjørklund S, Langberg S; Oslo Breast Cancer Consortium (OSBREAC), Kristensen VN, Vitelli V, Tekpli X, Fleischer T.NAR Cancer. 2022 Mar 24;4(1):zcac008. doi: 10.1093/narcan/zcac008. eCollection 2022 Mar.PMID: 35350772
Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer. Carm KT, Johannessen B, Bogaard M, Bakken AC, Maltau AV, Hoff AM, Axcrona U, Axcrona K, Lothe RA, Skotheim RI.Int J Cancer. 2022 Jul 26. doi: 10.1002/ijc.34226. Online ahead of print.PMID: 35880692
Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity. Strømme JM, Johannessen B, Kidd SG, Bogaard M, Carm KT, Zhang X, Sveen A, Mathelier A, Lothe RA, Axcrona U, Axcrona K, Skotheim RI.Cancer Gene Ther. 2022 Feb 22. doi: 10.1038/s41417-022-00444-7. Online ahead of print.PMID: 35194199
Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A Second Case. Panagopoulos I, Gorunova L, Andersen K, Lund-Iversen M, Hognestad HR, Lobmaier I, Micci F, Heim S.Cancer Genomics Proteomics. 2022 Jul-Aug;19(4):445-455. doi: 10.21873/cgp.20331.PMID: 35732319
Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity. Gorunova L, Boye K, Panagopoulos I, Berner JM, Bjerkehagen B, Hompland I, Lobmaier I, Hølmebakk T, Hveem TS, Heim S, Micci F.Oncotarget. 2022 Mar 7;13:508-517. doi: 10.18632/oncotarget.28209. eCollection 2022.PMID: 35284037
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets. Domanska D, Majid U, Karlsen VT, Merok MA, Beitnes AR, Yaqub S, Bækkevold ES, Jahnsen FL.J Exp Med. 2022 Feb 9;219(3):e20211846. doi: 10.1084/jem.20211846. Epub 2022 Feb 9.PMID: 35139155
miR-200a/b/-429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer. Nilsen A, Hillestad T, Skingen VE, Aarnes EK, Fjeldbo CS, Hompland T, Evensen TS, Stokke T, Kristensen GB, Grallert B, Lyng H.
A prognostic hypoxia gene signature with low heterogeneity within the dominant tumour lesion in prostate cancer patients. Salberg UB, Skingen VE, Fjeldbo CS, Hompland T, Ragnum HB, Vlatkovic L, Hole KH, Seierstad T, Lyng H.Br J Cancer. 2022 Jul;127(2):321-328. doi: 10.1038/s41416-022-01782-x. Epub 2022 Mar 24.PMID: 35332267
2021
Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients. Ramirez-Garrastacho M, Berge V, Linē A, Llorente A.Br J Cancer. 2021 Nov 22. doi: 10.1038/s41416-021-01598-1. Online ahead of print.PMID: 34811506
Multi-Omics Marker Analysis Enables Early Prediction of Breast Tumor Progression. Xu H, Lien T, Bergholtz H, Fleischer T, Djerroudi L, Vincent-Salomon A, Sørlie T, Aittokallio T.Front Genet. 2021 Jun 3;12:670749. doi: 10.3389/fgene.2021.670749. eCollection 2021.PMID: 34149812
Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer. Aure MR, Fleischer T, Bjørklund S, Ankill J, Castro-Mondragon JA; OSBREAC, Børresen-Dale AL, Tost J, Sahlberg KK, Mathelier A, Tekpli X, Kristensen VN.Genome Med. 2021 Apr 29;13(1):72. doi: 10.1186/s13073-021-00880-4.PMID: 33926515
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M,Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E. Rapid genome editing by CRISPR-Cas9-POLD3 fusion. Elife. 2021 Dec 13;10:e75415. doi: 10.7554/eLife.75415. PMID: 34898428; PMCID: PMC8747517.
Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA. The expressed mutational landscape of microsatellite stable colorectal cancers. Genome Med. 2021 Sep 1;13(1):142. doi: 10.1186/s13073-021-00955-2. PMID: 34470667; PMCID: PMC8411524.
Grad I, Hanes R, Ayuda-Durán P, Kuijjer ML, Enserink JM, Meza-Zepeda LA, Myklebost O. Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening. PLoS One. 2021 Mar 10;16(3):e0248140. doi: 10.1371/journal.pone.0248140. PMID: 33690666; PMCID: PMC7946228.
Georgiesh T, Namløs HM, Sharma N, Lorenz S, Myklebost O, Bjerkehagen B, Meza-Zepeda LA, Boye K. Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour. Pathology. 2021 Oct;53(6):713-719. doi: 10.1016/j.pathol.2020.11.010. Epub 2021 Mar 19. PMID: 33745702.
Boye K, Longhi A, Guren T, Lorenz S, Næss S, Pierini M, Taksdal I, Lobmaier I, Cesari M, Paioli A, Løndalen AM, Setola E, Hompland I, Meza-Zepeda LA, Sundby Hall K, Palmerini E. Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial. Cancer Immunol Immunother. 2021 Sep;70(9):2617-2624. doi: 10.1007/s00262-021-02876-w. Epub 2021 Feb 12. PMID: 33580363; PMCID: PMC8360887.
Hølmebakk T, Wiedswang AM, Meza-Zepeda LA, Hompland I, Lobmaier IVK, Berner JM, Stoldt S, Boye K. Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach. Ann Surg Oncol. 2021 Oct;28(11):6837-6845. doi: 10.1245/s10434-021-09605-8. Epub 2021 Mar 2. PMID: 33651216; PMCID: PMC8460510.
Bengtsen M, Winje IM, Eftestøl E, Landskron J, Sun C, Nygård K, Domanska D, Millay DP, Meza-Zepeda LA, Gundersen K. Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PLoS Genet. 2021 Nov 9;17(11):e1009907. doi: 10.1371/journal.pgen.1009907. PMID: 34752468; PMCID: PMC8604348.
Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ. Liv I B Sikkeland 1 2, Shuo-Wang Qiao 3 4, Thor Ueland 5 6 7, Ole Myrdal 2, Łukasz Wyrożemski 4, Pål Aukrust 5 6 7 8, Frode L Jahnsen 5 9, Tone Sjåheim 2, Johny Kongerud 5 2, Øyvind Molberg 5 10, May Brit Lund 5 2, Espen S Bækkevold 9 11 Eur Respir J. 2021 Mar 11;57(3):2000983. PMID: 33154027
Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia. Sohlberg E, Pfefferle A, Ask EH, Tschan-Plessl A, Jacobs B, Netskar H, Lorenz S, Kanaya M, Kosugi-Kanaya M, Meinke S, Mörtberg A, Höglund P, Sundin M, Carlsson G, Palmblad J, Malmberg KJ. Blood. 2021 Oct 26:blood.2021013233. doi: 10.1182/blood.2021013233. Online ahead of print. PMID: 34699594
Rare KMT2A-ELL and Novel ZNF56-KMT2A Fusion Genes in Pediatric T-cell Acute Lymphoblastic Leukemia.Panagopoulos I, Andersen K, Eilert-Olsen M, Rognlien AG, Munthe-Kaas MC, Micci F, Heim S. Cancer Genomics Proteomics. 2021 Mar-Apr;18(2):121-131. doi: 10.21873/cgp.20247. PMID: 33608309
Fusion of the Paired Box 3 (PAX3) and Myocardin (MYOCD) Genes in Pediatric Rhabdomyosarcoma.Panagopoulos I, Gorunova L, Andersen K, Lund-Iversen M, Tafjord S, Micci F, Heim S. Cancer Genomics Proteomics. 2021 Nov-Dec;18(6):723-734. doi: 10.21873/cgp.20293. PMID: 34697065
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes. Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT, Buechner J, Garcia KC, Schumacher TN, van Veelen PA, Leisegang M, Jacobsen SEW, Woll P, Olweus J. Nat Biotechnol. 2021 Dec 6. doi: 10.1038/s41587-021-01089-x. Online ahead of print. PMID: 34873326
The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology. Nakken S, Lilleby W, Switlyk MD, Knudsen KE, Lilleby O, Zhao S, Kaveh F, Ekstrøm PO, Urbanucci A, Hovig E. J Pers Med. 2021 Apr 22;11(5):330. doi: 10.3390/jpm11050330. PMID: 33922147
Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial. Aamdal E, Inderberg EM, Ellingsen EB, Rasch W, Brunsvig PF, Aamdal S, Heintz KM, Vodák D, Nakken S, Hovig E, Nyakas M, Guren TK, Gaudernack G. Front Immunol. 2021 May 11;12:663865. doi: 10.3389/fimmu.2021.663865. eCollection 2021.PMID: 34046035
Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer. Eide PW, Moosavi SH, Eilertsen IA, Brunsell TH, Langerud J, Berg KCG, Røsok BI, Bjørnbeth BA, Nesbakken A, Lothe RA, Sveen A. NPJ Genom Med. 2021 Jul 14;6(1):59. doi: 10.1038/s41525-021-00223-7. PMID: 34262039
APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease.Tunold JA, Geut H, Rozemuller JMA, Henriksen SP, Toft M, van de Berg WDJ, Pihlstrøm L.Front Neurol. 2021 Feb 5;12:631145. doi: 10.3389/fneur.2021.631145. eCollection 2021. PMID: 33613437
Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor. Öjlert ÅK, Nebdal D, Snapkov I, Olsen V, Kidman J, Greiff V, Chee J, Helland Å. Mol Oncol. 2021 Nov;15(11):2958-2968. doi: 10.1002/1878-0261.13082. Epub 2021 Sep 1. PMID: 34402187
Gene expression profile in cases of infectious death in infancy. Ferrante L, Opdal SH, Nygård S, Vege Å, Rognum TO. Pediatr Res. 2021 Feb;89(3):483-487. doi: 10.1038/s41390-020-0896-4. Epub 2020 Apr 16. PMID: 32299088
Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Bøe SL, Heintz KM, Hovig E, Hammarström C, Corthay A, Krauss S; Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020 Apr 24;3(1):196. doi: 10.1038/s42003-020-0916-2. PMID: 32332858
2020
Lavelle TJ, Alver TN, Heintz KM, Wernhoff P, Nygaard V, Nakken S, Øy GF, Bøe SL, Urbanucci A, Hovig E. Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes.Cancers (Basel). 2020 Jun 28;12(7):1719. doi: 10.3390/cancers12071719. PMID: 32605315
Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H. Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Adv. 2020 May 12;4(9):1859-1866. doi: 10.1182/bloodadvances.2019001325. PMID: 32374878
Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A. Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity. EBioMedicine. 2020 Sep;59:102923. doi: 10.1016/j.ebiom.2020.102923. Epub 2020 Aug 13. PMID: 32799124
Serguienko A, Braadland P, Meza-Zepeda LA, Bjerkehagen B, Myklebost O. Accurate 3-gene-signature for early diagnosis of liposarcoma progression. Clin Sarcoma Res. 2020 Mar 5;10:4. doi: 10.1186/s13569-020-0126-1. eCollection 2020. PMID: 32158531
Panagopoulos I, Gorunova L, Kostolomov I, Lobmaier I, Bjerkehagen B, Heim S. Chronic Expanding Hematoma with a t(11;19)(q13;q13) Chromosomal Translocation.Anticancer Res. 2020 Jan;40(1):97-100. doi: 10.21873/anticanres.13930. PMID: 31892557
Panagopoulos I, Gorunova L, Andersen K, Lund-Iversen M, Lobmaier I, Micci F, Heim S. NDRG1-PLAG1 and TRPS1-PLAG1 Fusion Genes in Chondroid Syringoma. Cancer Genomics Proteomics. 2020 May-Jun;17(3):237-248. doi: 10.21873/cgp.20184. PMID: 32345665
Fusion of the COL4A5 Gene With NR2F2-AS1 in a Hemangioma Carrying a t(X;15)(q22;q26) Chromosomal Translocation. Panagopoulos I, Gorunova L, Lobmaier I, Andersen K, Lund-Iversen M, Micci F, Heim S.Cancer Genomics Proteomics. 2020 Jul-Aug;17(4):383-390. doi: 10.21873/cgp.20197. PMID: 32576583
Panagopoulos I, Gorunova L, Andersen K, Lobmaier I, Lund-Iversen M, Micci F, Heim S. Fusion of the Lumican (LUM) Gene With the Ubiquitin Specific Peptidase 6 (USP6) Gene in an Aneurysmal Bone Cyst Carrying a t(12;17)(q21;p13) Chromosome Translocation. Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):555-561. doi: 10.21873/cgp.20211. PMID: 32859633
Małecka A, Delabie J, Østlie I, Tierens A, Randen U, Berentsen S, Tjønnfjord GE, Trøen G. Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18.Blood Adv. 2020 Mar 24;4(6):993-996. doi: 10.1182/bloodadvances.2020001608. PMID: 32168377
Ree AH, Nygaard V, Boye K, Heinrich D, Dueland S, Bergheim IR, Johansen C, Beiske K, Negård A, Lund-Iversen M, Nygaard V, Hovig E, Nakken S, Nasser S, Julsrud L, Reisse CH, Ruud EA, Kristensen VN, Flørenes VA, Geitvik GA, Lingjærde OC, Børresen-Dale AL, Russnes HG, Mælandsmo GM, Flatmark K.Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study. Acta Oncol. 2020 Jul;59(7):733-740. doi: 10.1080/0284186X.2020.1742377. Epub 2020 Mar 25. PMID: 32208873
Hillestad T, Hompland T, Fjeldbo CS, Skingen VE, Salberg UB, Aarnes EK, Nilsen A, Lund KV, Evensen TS, Kristensen GB, Stokke T, Lyng H. MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer. Cancer Res. 2020 Sep 15;80(18):3993-4003. doi: 10.1158/0008-5472.CAN-20-0950. Epub 2020 Jun 30. PMID: 32606004
Fjeldbo CS, Hompland T, Hillestad T, Aarnes EK, Günther CC, Kristensen GB, Malinen E, Lyng H. Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity. EBioMedicine. 2020 Jul;57:102841. doi: 10.1016/j.ebiom.2020.102841. Epub 2020 Jun 21. PMID: 32580139
Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO. A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation. Cancers (Basel). 2020 Jun 19;12(6):1630. doi: 10.3390/cancers12061630. PMID: 32575464
Sankar A, Lerdrup M, Manaf A, Johansen JV, Gonzalez JM, Borup R, Blanshard R, Klungland A, Hansen K, Andersen CY, Dahl JA, Helin K, Hoffmann ER. KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes. Nat Cell Biol. 2020 Apr;22(4):380-388. doi: 10.1038/s41556-020-0494-z. Epub 2020 Mar 30. PMID: 32231309
Pfefferle A, Jacobs B, Haroun-Izquierdo A, Kveberg L, Sohlberg E, Malmberg KJ. Deciphering Natural Killer Cell Homeostasis. Front Immunol. 2020 May 12;11:812. doi: 10.3389/fimmu.2020.00812. eCollection 2020. PMID: 32477340
Namløs HM, Boye K, Meza-Zepeda LA. Cell-free DNA in blood as a noninvasive insight into the sarcoma genome. Mol Aspects Med. 2020 Apr;72:100827. doi: 10.1016/j.mam.2019.10.004. Epub 2019 Nov 6. PMID: 31703948
Lossius AH, Berents TL, Saetre F, Nilsen HR, Bradley M, Asad S, Haraldsen G, Sundnes O, Holm JØ. Early transcriptional changes after UVB treatment in atopic dermatitis includes inverse regulation of IL-36γ and IL-37. Exp Dermatol. 2020 Oct 17. doi: 10.1111/exd.14217. Online ahead of print. PMID: 33067891
2019
Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A. Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer. Cancer Lett. 2020 Jan 28;469:246-255. doi: 10.1016/j.canlet.2019.10.040. Epub 2019 Oct 31. PMID: 31678167
Pashov A, Shivarov V, Hadzhieva M, Kostov V, Ferdinandov D, Heintz KM, Pashova S, Todorova M, Vassilev T, Kieber-Emmons T, Meza-Zepeda LA, Hovig E.. Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries. Front Immunol. 2019 Dec 3;10:2796. doi: 10.3389/fimmu.2019.02796. eCollection 2019. PMID: 31849974
Dominguez-Valentin M, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Holth A, Capella G, Davidson B, Evans DG, Martins A, Møller P, Hovig E. Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing. Sci Rep. 2019 Dec 6;9(1):18555. doi: 10.1038/s41598-019-54517-z. PMID: 31811167
Lund-Andersen C, Nakken S, Nygård S, Fromm B, Aasheim LB, Davidson B, Julsrud L, Abrahamsen TW, Kristensen AT, Dybdahl B, Larsen SG, Hovig E, Flatmark K. Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response. Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2). pii: a003566. doi: 10.1101/mcs.a003566. Print 2019 Apr. PMID: 30862609
Brunet A, Forsberg F, Fan Q, Sæther T, Collas P. Nuclear Lamin B1 Interactions With Chromatin During the Circadian Cycle Are Uncoupled From Periodic Gene Expression. Front Genet. 2019 Oct 3;10:917. doi: 10.3389/fgene.2019.00917. eCollection 2019. PMID: 31632442
Forsberg F, Brunet A, Ali TML, Collas P. Interplay of lamin A and lamin B LADs on the radial positioning of chromatin. Nucleus. 2019 Dec;10(1):7-20. doi: 10.1080/19491034.2019.1570810. PMID: 30663495
Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre MR, Fåne A, Gaudernack G, Kvalheim G, Myklebust JH, Inderberg EM, Wälchli S. NK cells specifically TCR-dressed to kill cancer cells. EBioMedicine. 2019 Feb;40:106-117. doi: 10.1016/j.ebiom.2019.01.031. Epub 2019 Jan 18. PMID: 30665853
Pfefferle A, Jacobs B, Netskar H, Ask EH, Lorenz S, Clancy T, Goodridge JP, Sohlberg E, Malmberg KJ. Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity. Cell Rep. 2019 Nov 19;29(8):2284-2294.e4. doi: 10.1016/j.celrep.2019.10.058. PMID: 31747601
Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ. Remodeling of secretory lysosomes during education tunes functional potential in NK cells. Nat Commun. 2019 Jan 31;10(1):514. doi: 10.1038/s41467-019-08384-x. PMID: 30705279
Paulsen J, Liyakat Ali TM, Nekrasov M, Delbarre E, Baudement MO, Kurscheid S, Tremethick D, Collas P. Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation. Nat Genet. 2019 May;51(5):835-843. doi: 10.1038/s41588-019-0392-0. Epub 2019 Apr 22. PMID: 31011212
Panagopoulos I, Gorunova L, Andersen HK, Pedersen TD, Lømo J, Lund-Iversen M, Micci F, Heim S. Genetic Characterization of Myoid Hamartoma of the Breast. Cancer Genomics Proteomics. 2019 Nov-Dec;16(6):563-568. doi: 10.21873/cgp.20158. PMID: 31659109
Panagopoulos I, Brunetti M, Stoltenberg M, Strandabø RAU, Staurseth J, Andersen K, Kostolomov I, Hveem TS, Lorenz S, Nystad TA, Flægstad T, Micci F, Heim S. Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype. Exp Hematol Oncol. 2019 May 29;8:12. doi: 10.1186/s40164-019-0136-y. eCollection 2019. PMID: 31161074
Panagopoulos I, Gorunova L, Lobmaier I, Lund-Iversen M, Andersen K, Holth A, Bjerkehagen B, Heim S. Fusion of the COL1A1 and FYN Genes in Epithelioid Osteoblastoma. Cancer Genomics Proteomics. 2019 Sep-Oct;16(5):361-368. doi: 10.21873/cgp.20141. PMID: 31467230
Panagopoulos I, Gorunova L, Lund-Iversen M, Bassarova A, Heim S. Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma. Cancer Genomics Proteomics. 2019 Sep-Oct;16(5):345-351. doi: 10.21873/cgp.20139. PMID: 31467228
Panagopoulos I, Lobmaier I, Gorunova L, Heim S. Fusion of the Genes WWTR1 and FOSB in Pseudomyogenic Hemangioendothelioma. Cancer Genomics Proteomics. 2019 Jul-Aug;16(4):293-298. doi: 10.21873/cgp.20134. PMID: 31243110
Panagopoulos I, Brunetti M, Stoltenberg M, Strandabø RAU, Staurseth J, Andersen K, Kostolomov I, Hveem TS, Lorenz S, Nystad TA, Flægstad T, Micci F, Heim S. Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype. Exp Hematol Oncol. 2019 May 29;8:12. doi: 10.1186/s40164-019-0136-y. eCollection 2019.
Saghaug CS, Klotz C, Kallio JP, Brattbakk HR, Stokowy T, Aebischer T, Kursula I, Langeland N, Hanevik K. Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates. Infect Drug Resist. 2019 May 10;12:1221-1235. doi: 10.2147/IDR.S177997. eCollection 2019. PMID: 31190910
2018
Poulsen LC, Edelmann RJ, Krüger S, Diéguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Bækkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisæter E, Hol J. Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers. Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):854-869. doi: 10.1161/ATVBAHA.117.310388. Epub 2018 Feb 15. PMID: 29449332
Nilsen A, Jonsson M, Aarnes EK, Kristensen GB, Lyng H. Reference MicroRNAs for RT-qPCR Assays in Cervical Cancer Patients and Their Application to Studies of HPV16 and Hypoxia Biomarkers. Transl Oncol. 2019 Mar;12(3):576-584. doi: 10.1016/j.tranon.2018.12.010. Epub 2019 Jan 17. PMID: 30660934
Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA. High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases. Clin Colorectal Cancer. 2019 Dec 12. pii: S1533-0028(19)30447-5. doi: 10.1016/j.clcc.2019.09.003. [Epub ahead of print]. PMID: 31982351
Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A. Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer. Cancer Lett. 2020 Jan 28;469:246-255. doi: 10.1016/j.canlet.2019.10.040. Epub 2019 Oct 31. PMID: 31678167
Eide PW, Eilertsen IA, Sveen A, Lothe RA. Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties. Int J Cancer. 2019 Jun 1;144(11):2843-2853. doi: 10.1002/ijc.31998. Epub 2019 Jan 12. PMID: 30447009
Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI. Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity. Eur Urol. 2019 Mar;75(3):498-505. doi: 10.1016/j.eururo.2018.08.009. Epub 2018 Sep 1. PMID: 30181068
Skaga E, Kulesskiy E, Fayzullin A, Sandberg CJ, Potdar S, Kyttälä A, Langmoen IA, Laakso A, Gaál-Paavola E, Perola M, Wennerberg K, Vik-Mo EO. Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma. BMC Cancer. 2019 Jun 25;19(1):628. doi: 10.1186/s12885-019-5861-4. PMID: 31238897
Forthun RB, Hovland R, Schuster C, Puntervoll H, Brodal HP, Namløs HM, Aasheim LB, Meza-Zepeda LA, Gjertsen BT, Knappskog S, Straume O. ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab. Sci Rep. 2019 Nov 25;9(1):17471. doi: 10.1038/s41598-019-53917-5. PMID: 31767937
Celestino R, Nome T, Pestana A, Hoff AM, Gonçalves AP, Pereira L, Cavadas B, Eloy C, Bjøro T, Sobrinho-Simões M, Skotheim RI, Soares P. CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension. BMC Cancer. 2018; 18: 68. PMID: 29321030
Jacobs B, Pfefferle A, Clement D, Berg-Larsen A, Saetersmoen ML, Lorenz S, Wiiger MT, Goodridge JP, Malmberg KJ. Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal. J Immunol. 2018 Dec 21. PMID: 30578306
Herrera CM, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM. Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity. Nucleic Acids Res. 2018 Dec 14;46(22):12188-12189. PMID: 30395271
Eide PW, Eilertsen IA, Sveen A, Lothe RA. Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell‐intrinsic properties. Int J Cancer. 2018 Nov 17. doi: 10.1002. PMID: 30447009
Vodák D, Lorenz S, Nakken S, Aasheim LB, Holte H, Bai B, Myklebost O, Meza-Zepeda LA, Hovig E. Sample-Index Misassignment Impacts Tumour Exome Sequencing. Sci Rep. 2018 Mar 28;8(1):5307. PMID: 29593270
Namløs HM, Boye K, Mishkin SJ, Barøy T, Lorenz S, Bjerkehagen B, Stratford EW, Munthe E, Kudlow BA, Myklebost O, Meza-Zepeda LA. Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor. Mol Cancer Ther. 2018 Nov;17(11):2473-2480. PMID: 30097488
Gouravan S, Meza-Zepeda LA, Myklebost O, Stratford EW, Munthe E. Preclinical Evaluation of Vemurafenib as Therapy for BRAFV600E Mutated Sarcomas. Int J Mol Sci. 2018 Mar 23;19(4). PMID: 29570692
Kresse SH1, Namløs HM1, Lorenz S1,2, Berner JM3, Myklebost O1,4,5, Bjerkehagen B3, Meza-Zepeda LA. Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples. PLoS One. 2018 May 17;13(5):e0197456. PMID: 29771965
Briand N, Guénantin AC, Jeziorowska D, Shah A, Mantecon M, Capel E, Garcia M, Oldenburg A, Paulsen J, Hulot JS, Vigouroux C, Collas P. The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks. Hum Mol Genet. 2018 Apr 15;27(8):1447-1459. PMID: 29438482
Mev Dominguez-Valentin, Sigve Nakken, Hélène Tubeuf, Daniel Vodak, Per Olaf Ekstrøm, Anke M. Nissen,Monika Morak, Elke Holinski-Feder, Alexandra Martins, Pål Møller and Eivind Hovig. Identification of genetic variants for clinical management of familial colorectal tumors. BMC Med Genet. 2018; 19: 26. PMID: 29458332
Dominguez-Valentin M, Evans DGR, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E. Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds. Hered Cancer Clin Pract. 2018 Jan 15;16:4. PMID: 29371908
Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI. Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity. Eur Urol. 2018 Sep 1. pii: S0302-2838(18)30594-3. PMID: 30181068
Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA. Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer. Int J Cancer. 2018 Aug 19. doi: 10.1002/ijc.31809. PMID: 30121958
Brunetti M, Gorunova L, Davidson B, Heim S, Panagopoulos I, Micci F. Identification of an EPC2-PHF1 fusion transcript in low-grade endometrial stromal sarcoma. Oncotarget. 2018 Apr 10;9(27):19203-19208. PMID: 29721194
Panagopoulos I, Gorunova L, Jacobsen EM, Andersen K, Micci F, Heim S. RUNX1-PDCD6 fusion resulting from a novel t(5;21)(p15;q22) chromosome translocation in myelodysplastic syndrome secondary to chronic lymphocytic leukemia. PLoS One. 2018 Apr 19;13(4):e0196181. PMID: 29672642
Panagopoulos I, Gorunova L, Andersen HK, Bergrem A, Dahm A, Andersen K, Micci F, Heim S. PAN3-PSMA2 fusion resulting from a novel t(7;13)(p14;q12) chromosome translocation in a myelodysplastic syndrome that evolved into acute myeloid leukemia. Exp Hematol Oncol. 2018 Mar 20;7:7. PMID: 29560286
Brunetti M, Panagopoulos I, Gorunova L, Davidson B, Heim S, Micci F. RNA-sequencing identifies novel GREB1-NCOA2 fusion gene in a uterine sarcoma with the chromosomal translocation t(2;8)(p25;q13). Genes Chromosomes Cancer. 2018 Apr;57(4):176-181. PMID: 29218853
2017
Eslamloo K, Inkpen SM, Rise ML, Andreassen R. Discovery of microRNAs associated with the antiviral immune response of Atlantic cod macrophages. Mol Immunol. 2018 Jan;93:152-161. doi: 10.1016/j.molimm.2017.11.015. Epub 2017 Nov 27. PMID: 29190475
Celestino R, Nome T, Pestana A, Hoff AM, Gonçalves AP, Pereira L, Cavadas B, Eloy C, Bjøro T, Sobrinho-Simões M, Skotheim RI, Soares P. CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension. BMC Cancer. 2018 Jan 10;18(1):68. doi: 10.1186/s12885-017-3948-3. PMID: 29321030
Jacob H, Stanisavljevic L, Storli KE, Hestetun KE, Dahl O, Myklebust MP. A four-microRNA classifier as a novel prognostic marker for tumor recurrence in stage II colon cancer. Sci Rep. 2018 Apr 18;8(1):6157. doi: 10.1038/s41598-018-24519-4. PMID: 29670141
Nakken S, Fournous G, Vodák D, Aasheim LB, Myklebost O, Hovig E.Personal Cancer Genome Reporter: variant interpretation report for precision oncology. Bioinformatics. 2017 Dec 20. doi: 10.1093
Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RAMulti-omics of 34 colorectal cancer cell lines - a resource for biomedical studies. Mol Cancer. 2017 16:116
Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA. Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1. Genome Medicine 2017 9:46
Andreassen R, Woldemariam NT, Egeland IO, Agafonov O, Sindre H, Høyheim B. Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection. BMC Genomics 2017 18:349
Helland Å, Brustugun OT, Nakken S, Halvorsen AR, Dønnem T, Bremnes R, Busund LT, Sun J, Lorenz S, Solberg SK, Jørgensen LH, Vodak D, Myklebost O, Hovig E, Meza-Zepeda LA. High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival. Int J Cancer. 2017 Jul 1;141(1):184-190
Rustad EH, Coward E, Skytøen ER, Misund K, Holien T, Standal T, Børset M, Beisvag V, Myklebost O, Meza-Zepeda LA, Dai HY, Sundan A, Waage A. Monitoring multiple myeloma by quantification of recurrent mutations in serum.
Haematologica. 2017 Jul;102(7):1266-1272Rodríguez M, Bajo-Santos C, Hessvik NP, Lorenz S, Fromm B, Berge V, Sandvig K, Linē A, Llorente A. Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes. Mol Cancer. 2017 Oct 5;16(1):156
Serguienko A, Hanes R, Grad I, Wang MY, Myklebost O, Munthe E. PP2A Regulatory Subunit B55γ is a Gatekeeper of Osteoblast Maturation and Lineage Maintenance. Stem Cells and Development. October 2017, 26(19): 1375-1383.
Namløs HM, Zaikova O, Bjerkehagen B, Vodák D, Hovig E, Myklebost O, Boye K, Meza-Zepeda. Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report. LA BMC Cancer. 2017 Jan 6;17(1):29.
Paulsen J, Sekelja M, Oldenburg AR, Barateau A, Briand N, Delbarre E, Shah A, Sørensen AL, Vigouroux C, Buendia B, Collas P. Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biology 2017; 18: 21.
Delbarre E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug JØ, Bøe SO, Wong LH, Küntziger T, Collas P. PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Res. 2017 Jun;27(6):913-921.
Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Fikstad KAM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H. Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition. British Journal of Cancer 2017, 115:929-9239
Namløs HM, Zaikova O, Bjerkehagen B, Vodák D, Hovig E, Myklebost O, Boye K, Meza-Zepeda LA. Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report. BMC Cancer. 2017 Jan 6;17(1):29. doi: 10.1186/s12885-016-2992-8.
Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM. TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity. Proc Natl Acad Sci U S A. 2017 Jan 17. pii: 201615093. doi: 10.1073/pnas.1615093114. [Epub ahead of print]
2016
Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad K-AM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Kjersti Flatmark and Lyng H. Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition. British Journal of Cancer 6 September 2016; doi: 10.1038/bjc.2016.278
Behnan J, Stangeland B, Langella T, Finocchiaro G, Murrell W, Brinchmann JE. Ultrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells. Sci Rep. 2016 Sep 8;6:32788. doi: 10.1038/srep32788.
Barøy T, Chilamakuri CS, Lorenz S, Sun J, Bruland ØS, Myklebost O, Meza-Zepeda LA. Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene. PLoS One. 2016 Sep 29;11(9):e0163859. doi: 10.1371/journal.pone.0163859.
Halvorsen AR, Silwal-Pandit L, Meza-Zepeda LA, Vodak D, Vu P, Sagerup C, Hovig E, Myklebost O, Børresen-Dale AL, Brustugun OT, Helland Å. TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients. Front Genet. 2016 May 11;7:85. doi: 10.3389/fgene.2016.00085.
Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA. Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations. Oncotarget. 2016 Feb 2;7(5):5273-88. doi: 10.18632/oncotarget.6567.
Ballinger ML, Goode DL, Ray-Coquard I, James PA, Mitchell G, Niedermayr E, Puri A, Schiffman JD, Dite GS, Cipponi A, Maki RG, Brohl AS, Myklebost O, Stratford EW, Lorenz S, Ahn SM, Ahn JH, Kim JE, Shanley S, Beshay V, Randall RL, Judson I, Seddon B, Campbell IG, Young MA, Sarin R, Blay JY, O'Donoghue SI, Thomas DM; International Sarcoma Kindred Study. Monogenic and polygenic determinants of sarcoma risk: an international genetic study. Lancet Oncol. 2016 Sep;17(9):1261-71. doi: 10.1016/S1470-2045(16)30147-4.
Oldenburg AR, Collas P. Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins. Methods Mol Biol. 2016;1411:315-24. doi: 10.1007/978-1-4939-3530-7_20.
Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI. Identification of Novel Fusion Genes in Testicular Germ Cell Tumors. Cancer Res. 2016 Jan 1;76(1):108-16. doi: 10.1158/0008-5472.CAN-15-1790.
Tambe M, Pruikkonen S, Mäki-Jouppila J, Chen P, Elgaaen BV, Straume AH, Huhtinen K, Cárpen O, Lønning PE, Davidson B, Hautaniemi S, Kallio MJ. Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel. Oncotarget. 2016 Mar 15;7(11):12267-85. doi: 10.18632/oncotarget.7860.
Andreassen R, Rangnes F, Sivertsen M, Chiang M, Tran M, Worren MM. Discovery of miRNAs and Their Corresponding miRNA Genes in Atlantic Cod (Gadus morhua): Use of Stable miRNAs as Reference Genes Reveals Subgroups of miRNAs That Are Highly Expressed in Particular Organs. PLoS One. 2016 Apr 29;11(4):e0153324. doi: 10.1371/journal.pone.0153324.
Kalanxhi E, Risberg K, Barua IS, Dueland S, Waagene S, Andersen SN, Pettersen SJ, Lindvall JM, Redalen KR, Flatmark K, Ree AH. Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy. Cancer Res Treat. 2016 Jul 28. doi: 10.4143/crt.2016.080. [Epub ahead of print]
Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG. Hypoxia-induced alterations of G2 checkpoint regulators. Mol Oncol. 2016 May;10(5):764-73. doi: 10.1016/j.molonc.2015.12.015. Epub 2016 Jan 8.
Våtsveen TK, Børset M, Dikic A, Tian E, Micci F, Lid AH, Meza-Zepeda LA, Coward E, Waage A, Sundan A1, Kuehl WM, Holien T. VOLIN and KJON-Two novel hyperdiploid myeloma cell lines. Genes Chromosomes Cancer. 2016 Jun 16. doi: 10.1002/gcc.22388. [Epub ahead of print]
Gervin K, Page CM, Aass HC, Jansen MA, Fjeldstad HE, Andreassen BK, Duijts L, van Meurs JB, van Zelm MC, Jaddoe VW, Nordeng H, Knudsen GP, Magnus P, Nystad W, Staff AC, Felix JF, Lyle R. Cell type specific DNA methylation in cord blood: a 450K-reference data set and cell count-based validation of estimated cell type composition. Epigenetics. 2016 Aug 5:0. [Epub ahead of print].
Hanes R, Grad I, Lorenz S, Stratford EW, Munthe E, Reddy CC, Meza-Zepeda LA, Myklebost O. Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma. Oncotarget. 2016 Jul 9. doi: 10.18632/oncotarget.10518. [Epub ahead of print].
Meltzer S, Kalanxhi E, Hektoen HH, Dueland S4, Flatmark K, Redalen KR, Ree AH. Systemic release of osteoprotegerin during oxaliplatincontaining induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer. Oncotarget. 2016 Apr 26. doi: 10.18632/oncotarget.8995. [Epub ahead of print].
Seip K, Fleten KG, Barkovskaya A, Nygaard V, Haugen MH, Engesæter BØ, Mælandsmo GM, Prasmickaite L. Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. Oncotarget. 2016 Apr 12;7(15):19997-20015. doi: 10.18632/oncotarget.7671.
Vandsemb EN, Bertilsson H, Abdollahi P, Størkersen Ø, Våtsveen TK, Rye MB, Rø TB, Børset M, Slørdahl TS. Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration. J Transl Med. 2016 Mar 15;14:71. doi: 10.1186/s12967-016-0830-z.
2015
Kierulf-Vieira KS, Sandberg CJ, Grieg Z, Günther CC, Langmoen IA, Vik-Mo EO. Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation. Exp Cell Res. 2016 Jan 1;340(1):53-61. doi: 10.1016/j.yexcr.2015.12.010. Epub 2015 Dec 19.
Bettum IJ, Gorad SS, Barkovskaya A, Pettersen S, Moestue SA, Vasiliauskaite K, Tenstad E, Øyjord T, Risa Ø, Nygaard V, Mælandsmo GM, Prasmickaite L. Metabolic reprogramming supports the invasive phenotype in malignant melanoma. Cancer Lett. 2015 Sep 28;366(1):71-83. doi: 10.1016/j.canlet.2015.06.006. Epub 2015 Jun 18.
Joel M, Mughal AA, Grieg Z, Murrell W, Palmero S, Mikkelsen B, Fjerdingstad HB, Sandberg CJ, Behnan J, Glover JC, Langmoen IA, Stangeland B. Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo. Mol Cancer. 2015 Jun 17;14:121. doi: 10.1186/s12943-015-0398-x.
Ollikainen M, Ismail K, Gervin K, Kyllönen A, Hakkarainen A, Lundbom J, Järvinen EA, Harris JR, Lundbom N, Rissanen A, Lyle R, Pietiläinen KH, Kaprio J. Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat. Clin Epigenetics. 2015 Apr 2;7:39. doi: 10.1186/s13148-015-0073-5. eCollection 2015.
Reppe S, Noer A, Grimholt RM, Halldórsson BV, Medina-Gomez C, Gautvik VT, Olstad OK, Berg JP, Datta H, Estrada K, Hofman A, Uitterlinden AG, Rivadeneira F, Lyle R, Collas P, Gautvik KM. Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women. J Bone Miner Res. 2015 Feb;30(2):249-56. doi: 10.1002/jbmr.2342.
Lando M, Fjeldbo CS, Wilting SM, Snoek B, Aarnes EK, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H. Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer. Epigenetics, (2015) (in press).
Lund EG, Duband-Goulet I, Oldenburg A, Buendia B, Collas P. Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin. Nucleus. 2015;6(1):30-9.
Joel M, Mughal AA, Grieg Z, Murrell W, Palmero S, Mikkelsen B, Fjerdingstad HB, Sandberg CJ, Behnan J, Glover JC, Langmoen I, Stangeland B. Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumorgrowth in vivo. Mol Cancer. 2015 Jun 17;14(1):121.Rustad EH, Dai HY, Hov H, Coward E, Beisvag V, Myklebost O, Hovig E, Nakken S, Vodak D, Meza-Zepeda LA, Sandvik A, Wader KF, Misund K, Sundan A, Aarset H and Waage A. Clinical and biological implications of BRAF V600E mutation in multiple myeloma. Blood Cancer Journal. (2015) Mar 20;5:e299.
Serguienko A, Grad I, Wennerstrøm AB, Meza-Zepeda LA, Thiede B, Stratford EW, Myklebost O and Munthe E. Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA. Oncotarget. (2015) Feb 10;6(4):2451-65.
Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Martin Peifer M, Plenker D, Heuckman JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z, Solomon B, Petersen I, Clement JH, Sänger J, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M, Buettner R, Wolf J, Brambilla E, Vingron M, Perner S, Haas SA and Thomas RK. Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biology. (2015)Jan 5;16(1):7.
2014
Garsed DW, Marshall OJ, Corbin VDA, Hsu A, Popkiss S, Li J, Feng Z-P, Kim BW, Kowarsky M, Lansdell B, Brookwell R, Myklebost O,Meza-Zepeda LA, Holloway AJ, Copin A, Pedeutour F, Choo KHAC, D’Amore M, Anthony T. Papenfuss AT and Thomas DM. The Architecture and Evolution of a Cancer Neochromosome. Cancer Cell. (2014) Nov 10;26(5):653-67.
Chilamakuri CSR, Lorenz S, Madoui M-A, Vodák D, Sun J, Hovig E, Myklebost O and Meza-Zepeda LA. Performance comparison of four exome capture systems for deep sequencing. BMC Genomics. (2014) Jun 9;15:449 HIGHLY ACCESSED.
Johansen I and Andreassen R. Validation of miRNA genes suitable as reference genes in qPCR analyses of miRNA gene expression in Atlantic salmon (Salmo salar). BMC Research Notes 2014, 7:945.
Håkelien A-M, Bryne, JC, Harstad KG, Lorenz S, Paulsen J, Sun J, Mikkelsen TS, Myklebost O and Meza-Zepeda LA. The regulatory landscape of osteogenic differentiation. Stem Cells. (2014) Oct;32(10):2780-93.
Skårn M, Noordhuis P, Wang MY, Veuger MJT, SH Kresse SH, Egeland EV, Micci F, Namløs HM, Håkelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA and Myklebost O. Generation and Characterization of an Immortalized Human Mesenchymal Stromal Cell Line. Stem Cells and Development. (2014) Oct 1;23(19):2377-89.
Barøy T, Kresse SH, Skårn M, Stabell M, Castro R, Lauvrak S, Llombart-Bosch A, Myklebost O and Meza-Zepeda LA. Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model. Molecular Cancer. (2014) Apr 28;13:93.
2013
Nome T, Thomassen GOS, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rongnum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA and Skotheim RI. Common fusion transcripts identified in colorectal cancer cell lines by high throughput RNA sequencing. Translational Oncology. (2013) Oct 1;6(5):546-53. eCollection.
Ragnum HB1, Røe K, Holm R, Vlatkovic L, Nesland JM, Aarnes EK, Ree AH, Flatmark K, Seierstad T, Lilleby W, Lyng H. Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer. Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):753-60.
Lauvrak SU, Munthe E, Kresse SH, Stratford EW, Namløs HM,Meza-Zepeda LAand Myklebost O. Functional characterization of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes. British Journal of Cancer. (2013) Oct 15;109(8):2228-36.
Schee K, Lorenz S, Molton Worren M, Günther C-C, Holden M, Hovig E, Fodstad Ø, Meza-Zepeda LA, Flatmark K. Deep sequencing the microRNA transcriptome in colorectal cancer. PLoS One. (2013) Jun 18;8(6):e66165.
Kuijjer ML, Peterse EF, van den Akker BE, Briaire-de Bruijn IH, Serra M, Meza-Zepeda LA, Myklebost O, Hassan AB, Hogendoorn PC and Cleton-Jansen AM. IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma. BMC Cancer. (2013) 20;13(1):245.
Qu S, Olafsrud SM, Meza-Zepeda LA, Saatcioglu F. Rapid Gene Expression Changes in Peripheral Blood Lymphocytes upon Practice of a Comprehensive Yoga Program. PLoS One. (2013) 8(4):e61910.
Herlofsen SR, Bryne JC, Høiby T, Wang L, Issner R, Zhang X, Coyne MJ, Boyle P, Gu H, Meza-Zepeda LA, Collas P, Mikkelsen TS, Brinchmann JE. Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics. (2013) 14(1):105.
Andreassen R, Worren MM and Høyheim B. Discovery and characterization of miRNA genes in atlantic salmon (Salmosalar) by use of a deep sequencing approach. BMC Genomics. 2013 Jul 17;14:482.
Ohnstad HO, CastroR, Sun J, Heintz K-M,Vassilev LT, BjerkehagenB, Kresse SH, Meza-Zepeda LA and Myklebost O. TP53 and MDM2 status can determine response to therapies in sarcomas. Cancer. (2013) 119(5):1013-22. BMCGenomics2013,14:482.
Lando M, Wilting SM, Snipstad K, Clancy T, Bierkens M, Aarnes EK, Holden M, Stokke T, Sundfør K, Holm R, Kristensen GB, Steenbergen RD, Lyng H. Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling. J Pathol. (2013). [Epub ahead of print].
Bjørnstad L, Meza TJ, Otterlei M, Olafsrud SM, Meza-Zepeda LA and Falnes P. The human AlkB homologue 4 interacts with proteins associated with transcription. PLoS One. (2012) 7(11):e49045.
Namløs HM, Meza-Zepeda LA, Barøy T, Østensen IHG, Stine H Kresse SH, Kuijjer ML, Serra M, Cleton-JansenA-M and Myklebost O. Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs. PLoS One. (2012) 7(10):e48086.
Kresse SH, Rydbeck H, Skårn M, Namløs HM, Barragan-Polania AH, Cleton-Jansen A-M, Serra M, Liestøl K, Hogendoorn PCW, Hovig E, Myklebost O and Meza-Zepeda LA. Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. PLoS One. (2012)7(11):e48262.
Ohnstad HO, CastroR, Sun J, Heintz K-M,Vassilev LT, BjerkehagenB, Kresse SH, Meza-Zepeda LA and Myklebost O. TP53 and MDM2 status can determine response to therapies in sarcomas. Cancer. (2013) 119(5):1013-22.
2012
Reikvam DH, Derrien M, Islam R, Erofeev A, Grcic V, Sandvik A, Gaustad P, Meza-Zepeda LA, Jahnsen FL, Smidt H, Johansen FE. Epithelial-microbial cross-talk in polymeric Ig receptor deficient mice. European Journal of Immunology (2012) Nov;42(11):2959-70.
Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA and Enserink JM. Cdc28 Kinase activity regulates the basal transcription machinery at a subset of genes. Proceedings of the National Academy of Sciences. (2012) 109(26):10450-5.
Kuijjer ML, Rydbeck H, Kresse SH, Buddingh EP, Lid AB, Roelofs H, Bürger H, Myklebost O, Hogendoorn PC, Meza-Zepeda LA, Cleton-Jansen AM. Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data. Genes Chromosomes and Cancer. (2012) Jul;51(7):696-706.
Skårn M, Namløs HM, Noordhuis P, Wang MY, Meza-Zepeda LA, Myklebost O. Adipocyte Differentiation of Human Bone Marrow-Derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222. Stem Cells Development. (2012) Apr 10;21(6):873-83.
Kresse SH, Meza-Zepeda LA, Machado I, Llombart-Bosch A and Myklebost O. Preclinical Xenograft models of human sarcoma show nonrandom loss of aberrations. Cancer, (2012). 118(2):558-70.
Kalanxhi E and Dahle J. Transcriptional responses in irradiated and bystander fibroblasts after low dose α-particle radiation. International Journal of Radiation Biology, (2012) Oct;88(10):713-719.
Kalanxhi E and Dahle J. Genome-Wide Microarray Analysis of Human Fibroblasts in Response to γ Radiation and the Radiation-Induced Bystander Effect. Radiation Research, (2012), 177(1):35-43.
Halle C, Andersen E, Lando M, Aarnes E-K, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, B. Kristensen GB, Holm R, Malinen E and Lyng H. Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI. Cancer Research, (2012) 72; 5285.
Gervin K, Vigeland MD, Mattingsdal M, Hammerø M, Nygård H, Olsen AO, Brandt I, Harris JR, Undlien DU and Lyle R. DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes. PLoS Genet. (2012) 8(1): e1002454.
2011
Dahlback H-S, Brandal P, Krossnes BK, Fric R, Meling TR, Meza-Zepeda LA, Danielsen HE and Heim S. Multiple chromosomal monosomies are characteristic of giant cell ependymoma. Human Pathology, (2011) Dec;42(12):2042-6.
Kuijjer ML, Namløs HM, Hauben EI, Machado I, Kresse SH, Serra M, Llombart-Bosch A, Hogendoorn PCW, Meza-Zepeda LA, Myklebost O and Cleton-Jansen AM. mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts. BMC Medical Genomic. (2011) 20;4:66.
Hjortland GO, Meza-Zepeda LA, Beiske K, Ree AH, Tveito S, Hoifodt H, Bohler PJ, Hole KH, Myklebost O, Fodstad O, Smeland S, Hovig E. Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma. BMC Cancer. (2011) Oct 20;11(1):455.
Halle C, Lando M, Svendsrud DH, Clancy T, Holden M, Sundfør L, Kristensen GB, Holm R, and Lyng H. Membranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor Predicts Outcome after Chemoradiotherapy of Lymph Node–Negative Cervical Cancer. Clinical Cancer Research (2011) 17; 5501.
Halle C, Lando M, Sundfør K, Kristensen GB, Holm R, Lyng H. Phosphorylation of EGFR measured with in situ proximity ligation assay: Relationship to EGFR protein level and gene dosage in cervical cancer. Radiotherapy and Oncology (2011) 101 (1): 152–157.
Herlofsen SR, Küchler AX, Melvik JE and Brinchmann JE. Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Self-Gelling Alginate Discs Reveals Novel Chondrogenic Signature Gene Clusters. Tissue Engineering Part A. (2011) 17(7-8): 1003–1013.
News
The Genomics Core Facility has successfully gone through a certification process to become a certified NGS ProLab for TWIST Bioscience technologies.
The Genomics Core Facility at Oslo University Hospital and University of Oslo is now a Core Lab for nCounter and GeoMx technologies.
Contact Information:
Genomics@rr-research.no
Daily Leader Core Facility
Susanne Lorenz, PhD
Susanne.Lorenz@rr-research.no
Head of Core Facility
Leonardo A. Meza-Zepeda, Dr. philos.
L.A.Meza-Zepeda@ous-research.no
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Visiting address:
Genomics Core Facility (Room 3-F8-04)
Department of Core facilities
Institute for Cancer Research
New OCCI-building
Norwegian Radium Hospital
Ullernchaussen 66, Lamell 3, 2B
NO-0379 Oslo, NORWAY
+47 - 9183 2772 Laboratory
+47 - 9183 3425 Office
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